What are the best biking bags?

I love my Chrome bag. Its sturdy as all hell and comfortable to ride with.

I've always liked my Chrome bag, but there's no hiding how much more awesome most of the smaller companies are. Chrome's quality control has plummeted since they got huge. Vaya is pretty awesome, especially if you're into women-owned companies and completely handmade stuff. Also, several of my messenger buddies swear by their Baileyworks Bags. Try a few out, none are the same.